MECHANISM OF ACTION
Clinical research has shown that MBP® maintains normal bone metabolism and structure(1) by:
- Encouraging healthy bone remodeling. MBP increases the number of osteoblasts (cells that build bone) and inhibits the activity of osteoclasts (cells that break down bone)(2).*
- Promoting collagen formation. Calcium is needed for bone strength, but without collagen, it has no place to attach to bone. By increasing collagen production, MBP helps calcium stick to bone(3–6).*
When a bone becomes unhealthy, osteoclasts function excessively and elute too much calcium
When MBP Goes To Work
Osteoblasts are activated, excessive osteoclast activity is inhibited, and the bone returns to health
References
- Yamamura J, Aoe S, Toba Y, et al. Milk basic protein (MBP) increases radial bone mineral density in healthy adult women. Biosci Biotechnol Biochem. 2002;66(3):702–704.
- Toba Y, Takada Y, Matsuoka Y, et al. Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men. Biosci Biotechnol Biochem. 2001;65(6):1353–1357.
- Aoe S, Toba Y, Yamamura J, Kawakami H, et al. Controlled trial of the effects of milk basic protein (MBP) supplementation on bone metabolism in healthy adult women. Biosci Biotechnol Biochem. 2001;65(4):913–918.
- Uenishi K, Ishida H, Toba Y, et al. Milk basic protein increases bone mineral density and improves bone metabolism in healthy young women. Osteoporos Int. 2007;18(3):385–390.
- Aoyagi Y, Park H, Park S, et al. Interactive effects of milk basic protein supplements and habitual physical activity on bone health in older women: A 1-year randomized controlled trial. Int Dairy J. 2010;20:724–730.
- Aoe S, Koyama T, Toba Y, et al. A controlled trial of the effect of milk basic protein (MBP) supplementation on bone metabolism in healthy menopausal women. Osteoporos Int. 2005;16(12):2123–2128.